Knot
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Knots are clusters of spiders found most commonly huddled in corners of rooms, but can also occasionally be encountered in corners created by obstacles.
When damaged or approached, Knots will spawn any combination of 3 Spiders or
Skuzzes, as well as 2 medium-sized Spider enemies:
They cannot be killed no matter the amount of damage they take, and will always spawn their swarm of spiders while fading away.
Knots do not need to be killed to clear a room, but remain active even once the room is cleared. They will disappear once Isaac leaves the room.
Trivia
- Knot was originally from the unreleased Morbus MOD.