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Bosses are very strong monsters found in Boss Pool Icon.png Boss Rooms at the end of a floor.

Fiend Folio adds 27 bosses and 3 mini-bosses into The Binding of Isaac: Repentance.

Disambig.png This page is about Bosses added in Fiend Folio. More information about Bosses in general can be found in the vanilla page.


Chapter 1

Chapter 1.5

Chapter 2

Chapter 3

Chapter 3.5

Chapter 4

Chapter 4.5


Three new Mini-Bosses have been added to ruin your day! Psion has taken over SheolIcon.png Sheol to usurp Satan, and Gravedigger rises foes from the dead to help her conquer the CathedralIcon.png Cathedral. Both of these Mini-Bosses will appear in their own Mini-Boss Room in their respective floors.

Additionally, if you have Risks Reward.png Risk's Reward, you can fight the Hermit!

Vanilla Boss Champions

Existing bosses within The Binding of Isaac: Repentance have also gotten some attention, as Fiend Folio includes 13 new champion variants, each with their own unique appearance.