Item Tags stackable

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Fiend Folio: Reheated adds an internal list of items whose effects can compound on each other when Isaac obtains multiple copies — this primarily consists of items that improve Isaac's attributes or grant him familiars, but a few other items have much more unique effects when stacked.

Broken Record Broken Record and Loaded D6 Loaded D6 will reroll items on pedestals into a copy of these items if Isaac has them in his inventory, and can summoned when using BrokenDisc.png Broken Disc.

Vanilla Stackable Items

Name Icon Quote Description Quality
The Sad Onion
The Sad Onion
Tears up
3
The Inner Eye
The Inner Eye
Triple shot
  • ×0.51 fire rate multiplier.
  • Isaac fires a spread of 3 tears at once.
2
Cricket's Head
Cricket's Head
DMG up
  • +0.5 damage.
  • ×1.5 damage multiplier.
4
Brother Bobby
Brother Bobby
Friends 'till the end
  • Spawns a familiar that follows Isaac around and shoots tears that deal 3.5 damage.
1
1up!
1up!
Extra life
  • +1 extra life.
  • On death, Isaac respawns in the previous room with full health.
2
Magic Mushroom
Magic Mushroom
All stats up!
4
The Virus
The Virus
Poison touch + speed up
  • Inflicts poison on enemies that make contact with Isaac (48 dmg per second).
  • Also lets Isaac deal contact damage to enemies (24 dmg every tick).
  • +0.2 speed.
2
Roid Rage
Roid Rage
Speed and range up
2
Wooden Spoon
Wooden Spoon
Speed up
1
The Belt
The Belt
Speed up
1
Mom's Underwear
Mom's Underwear
Range up
1
Mom's Heels
Mom's Heels
Range up
  • +2.5 range.
  • Makes Isaac deal 12 contact damage per tick.
1
Mom's Lipstick
Mom's Lipstick
Range up
1
Wire Coat Hanger
Wire Coat Hanger
Tears up
3
Lucky Foot
Lucky Foot
Luck up
  • +1 luck.
  • Increases the chances of certain machines and beggars to pay out with a reward.
  • Increases the chance of getting a room-clear reward.
  • Converts negative PillVanilla.png pills into their positive counterparts but does not identify them.
2
Steven
Steven
DMG up
3
Pentagram
Pentagram
DMG up
3
Dr. Fetus
Dr. Fetus
???
  • ×0.4 fire rate multiplier.
  • Replaces Isaac's tears with bombs that explode after approximately 1 second after being fired.
4
Distant Admiration
Distant Admiration
Attack fly
  • Spawns a red attack fly that circles around Isaac and deals 5 damage per tick.
2
Charm of the Vampire
Charm of the Vampire
DMG up + kills heal
1
Steam Sale
Steam Sale
50% off
  • Reduces all Shop Pool Icon.png Shop prices by 50%, rounded down to 7 coins for an item, rounded up to 2-3 coins for a pickup.
2
Sister Maggy
Sister Maggy
Friends 'till the end
  • Spawns a familiar that follows Isaac around and shoots red tears that deal 6 damage.
1
Technology
Technology
Laser tears
  • Replaces Isaac's tears with a laser beam that has unlimited range and Piercing.
3
Growth Hormones
Growth Hormones
Speed + DMG up
3
Mini Mush
Mini Mush
Speed + range up
  • +0.3 speed.
  • +1.5 range.
  • Decreases Isaac's size and hitbox size.
2
Cube of Meat
Cube of Meat
Gotta meat 'em all
  • Spawns an orbital familiar which blocks shots and deals contact damage.
  • The familiar can be upgraded up to 4 times by obtaining additional Cubes of Meat. Each level has its own characteristics.
2
The Mark
The Mark
DMG + speed up
3
The Pact
The Pact
DMG + tears up
3
Dead Cat
Dead Cat
9 lives
  • +9 extra lives.
  • Sets Isaac's HUD heart red full.png Red Heart containers to 1.
  • Upon death respawns Isaac in the previous room and sets his red heart containers to 1 again.
3
Lord of the Pit
Lord of the Pit
Demon wings
3
Little Chubby
Little Chubby
Attack buddy
  • Spawns a familiar that follows Isaac and charges across the room when Isaac shoots, dealing 3.5 damage per tick to any enemies in its path, until it hits a wall or obstacle.
2
The Small Rock
The Small Rock
DMG up + speed down
3
Sack of Pennies
Sack of Pennies
Gives money
  • Spawns a sack familiar that follows Isaac around and drops a random Penny.png coin every 2 rooms.
1
Robo-Baby
Robo-Baby
Friends 'till the bbbbzzzt
  • Spawns a familiar that follows Isaac and shoots Spectral Technology.png Technology lasers that deal 3.5 damage.
1
Little C.H.A.D.
Little C.H.A.D.
Gives kisses
  • Spawns a familiar that follows Isaac and drops a Half Red Heart.png Half Red Heart every 3 rooms.
2
The Relic
The Relic
Soul generator
  • Spawns a small blue cross familiar that follows Isaac around and drops a HUD heart soul full.png Soul Heart every 7 or 8 rooms alternatingly.
3
Little Gish
Little Gish
Sticky friend
  • Spawns a familiar that follows Isaac around and fires that afflict Slow and deal 3.5 damage.
2
Little Steven
Little Steven
Psychic friend
  • Spawns a familiar that follows Isaac around and fires Homing tears that do 3.5 damage.
2
The Halo
The Halo
All stats up
2
Money = Power
Money = Power
$$$ = DMG
3
Mom's Contacts
Mom's Contacts
Freeze effect
  • +1.5 range.
  • Adds a chance to shoot tears that afflict Petrified to enemies.
3
Guardian Angel
Guardian Angel
Extra protection
  • Spawns an orbital familiar that blocks enemy shots and deals 7 damage per tick.
  • Increases the speed of all orbiting familiars.
2
Demon Baby
Demon Baby
Auto-turret friend
  • Spawns a familiar that follows Isaac and automatically fires at enemies in its range 3 times per second, dealing 3 damage per shot.
2
Mom's Knife
Mom's Knife
Stab stab stab
  • Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it.
  • Holding down the fire button before firing increases its range and power.
4
Dead Bird
Dead Bird
Protective buddy
  • Taking damage summons a bird familiar that chases enemies for the remainder of the room, dealing 2 damage per tick.
0
Brimstone
Brimstone
Blood laser barrage
  • ×0.33 fire rate multiplier.
  • Replaces Isaac's tears with a laser beam that must be charged.
  • The beam pierces through enemies and obstacles and has infinite range.
4
Odd Mushroom
Odd Mushroom
Tears up + damage down
2
Odd Mushroom
Odd Mushroom
HP + DMG up, speed down
2
Whore of Babylon
Whore of Babylon
Curse up
2
Forever Alone
Forever Alone
Attack fly
  • Spawns a blue orbital fly that orbits a long distance from Isaac and deals 2 damage per tick.
1
Stigmata
Stigmata
DMG + HP up
2
Pageant Boy
Pageant Boy
Ultimate grand supreme
  • Spawns 7 random Penny.png coins on the ground.
0
Speed Ball
Speed Ball
Speed + shot speed up
2
Mutant Spider
Mutant Spider
Quad shot
  • ×0.42 fire rate multiplier.
  • Isaac fires a spread of 4 tears at the same time.
3
Chemical Peel
Chemical Peel
DMG up
  • +2 flat damage to tears fired from Isaac's left eye.
2
The Peeper
The Peeper
Plop!
  • ×1.35 damage multiplier to tears fired from Isaac's left eye.
  • Spawns a familiar that floats diagonally across the room and bounces off of walls, which blocks enemy shots and deals 8 damage per tick.
2
Ghost Baby
Ghost Baby
Spectral buddy
  • Spawns a familiar that follows Isaac around and fires Spectral tears that deal 3.5 damage.
1
Cat-O-Nine-Tails
Cat-O-Nine-Tails
Shot speed + damage up
3
Harlequin Baby
Harlequin Baby
Double shot buddy
  • Spawns a familiar that follows Isaac around and fires 2 tears at once in a V pattern which each deal 4 damage.
1
Epic Fetus
Epic Fetus
On-demand air strike
  • Replaces Isaac's tears with guided missiles.
4
Daddy Longlegs
Daddy Longlegs
Daddy's love
  • Daddy Long Legs' shadow follows Isaac and occasionally stomps enemies for 40 damage total.
3
Sacrificial Dagger
Sacrificial Dagger
My fate protects me
  • Spawns a dagger that orbits around Isaac, blocking enemy shots and deals 15 damage per tick.
2
Rainbow Baby
Rainbow Baby
Random buddy
  • Spawns a familiar that follows Isaac around and shoots tears that have random effects similar to other familiars.
1
Holy Water
Holy Water
Splash!
  • Grants a bottle familiar that flies forward when Isaac shoots.
  • It breaks upon hitting an enemy, leaving a puddle of blue creep that petrifies enemies.
3
Sacred Heart
Sacred Heart
Homing shots + DMG up
4
Toothpicks
Toothpicks
Tears + shot speed up
3
Guppy's Hairball
Guppy's Hairball
Swing it
  • Spawns a hairball familiar that loosely follows behind Isaac, which can block shots and be swung to damage enemies, dealing 5 damage per tick.
  • Each time it kills an enemy, it grows in size and its damage increases by +2. It can grow up to 5 times, for a maximum of 13 damage per tick.
1
Abel
Abel
Mirrored buddy
  • Spawns a familiar that mirrors Isaac's movement and shoots tears towards him that deal 3.5 damage to enemies.
0
SMB Super Fan
SMB Super Fan
All stats up
3
MEAT!
MEAT!
DMG + HP up
2
Magic 8 Ball
Magic 8 Ball
Shot speed up
1
Squeezy
Squeezy
Tears up
3
Jesus Juice
Jesus Juice
Damage + range up
2
Iron Bar
Iron Bar
DMG up + concussive tears
  • +0.3 damage.
  • Grants a chance to shoot tears that cause Confusion to enemies.
2
Guillotine
Guillotine
DMG + tears up. An out-of-body experience!
  • +1 damage.
  • +0.5 tears.
  • Detaches Isaac's head from his body, and makes it rotate around his body, allowing it to deal contact damage and block projectiles.
2
Ball of Bandages
Ball of Bandages
Gotta lick 'em all!
  • Spawns an orbital familiar which blocks shots and deals contact damage.
  • The familiar can be upgraded up to 4 times by obtaining additional Balls of Bandages. Each level has its own characteristics.
2
Champion Belt
Champion Belt
DMG + challenge up
  • +1 damage.
  • Increases the chance for champion enemies to appear by 15%.
3
Ceremonial Robes
Ceremonial Robes
DMG + evil up
3
Anti-Gravity
Anti-Gravity
Anti-gravity tears + tears up
  • +1 fire rate.
  • Holding the fire button causes tears to hover in midair. Upon releasing the button, tears are shot in the direction they were originally fired at.
2
Mom's Perfume
Mom's Perfume
Fear shot + tears up
  • +0.5 fire rate.
  • Adds a chance to shoot Fear tears that cause enemies to run away from Isaac.
2
Monstro's Lung
Monstro's Lung
Charged burst attack
  • ×0.23 fire rate multiplier.
  • Replaces Isaac's tears with a charge-attack that fires a barrage of 14 tears, similarly to Monstro.png Monstro.
2
Abaddon
Abaddon
Evil + DMG up + fear shot
3
Death's Touch
Death's Touch
Piercing shots + DMG up
3
Contract From Below
Contract From Below
Wealth... but at what cost?
  • Any reward spawned from clearing a room is doubled, but has a 33% chance to be removed completely.
3
20/20
20/20
Double shot
  • Isaac fires two tears at once, one from each eye.
  • 0.8× damage multiplier.
4
BOGO Bombs
BOGO Bombs
1+1 BOOM!
1
Screw
Screw
Tears + shot speed up
3
Smart Fly
Smart Fly
Revenge fly
  • Spawns a fly familiar that orbits Isaac, blocks projectiles and deals 1.5 damage per tick.
  • Upon taking damage in the room, the fly will seek out nearby enemies and attack them, losing the ability to block projectiles.
2
Dry Baby
Dry Baby
Immortal friend
  • Spawns a familiar that follows Isaac and blocks enemy projectiles. Upon blocking a shot, it has a 10% chance of triggering The Necronomicon.png The Necronomicon effect.
3
Juicy Sack
Juicy Sack
Sticky babies
  • Spawns a familiar that follows Isaac and leaves a trail of white creep that afflicts Slow to enemies.
  • Spawns 1-2 Blue Spider.png blue spiders after every room.
2
Robo-Baby 2.0
Robo-Baby 2.0
We worked out all the kinks
  • Spawns a familiar that can be moved around with the shooting buttons and automatically shoots Technology.png Technology lasers at enemies when aligned with them, dealing 3.5 damage per shot.
1
Rotten Baby
Rotten Baby
Infested friend
  • Spawns a familiar that follows Isaac and spawns a Blue Fly.png blue fly when in a room with enemies and holding down a fire button.
  • The familiar can spawn only one blue fly at a time.
3
Headless Baby
Headless Baby
Bloody friend
  • Spawns a familiar that follows Isaac and leaves a trail of damaging red creep on the ground that deals 2 damage per tick.
1
Leech
Leech
Blood sucker
  • Spawns a familiar that follows Isaac and attacks nearby enemies, dealing 1.5 damage per tick and healing Isaac for a Half Red Heart.png Half Red Heart upon killing an enemy.
2
Mystery Sack
Mystery Sack
?
  • Spawns a familiar that follows Isaac and drops a Red Heart.png Heart, Penny.png Coin, Bomb.png Bomb or Key.png Key every 5 or 6 rooms.
  • Pickups can be of any variant.
2
BBF
BBF
Big Beautiful Fly
  • Spawns a familiar that flies around the room diagonally and explodes upon contact with an enemy.
  • After exploding, respawns after 10 seconds.
1
Bob's Brain
Bob's Brain
Explosive thoughts
  • Spawns a familiar that flies forward when shooting.
  • If it hits an enemy, it explodes, dealing damage and poisoning enemies in the blast radius.
  • After exploding, respawns after a few seconds.
1
Lil Brimstone
Lil Brimstone
Evil friend
  • Grants a familiar that charges a thin Brimstone.png Brimstone laser that deals 3 damage per tick while Isaac is shooting.
2
Isaac's Heart
Isaac's Heart
Protect it
  • Spawns a heart familiar that follows Isaac and tries to position itself in the opposite direction of his shooting.
  • Isaac becomes invulnerable but takes damage if the heart gets hurt.
  • The heart charges up as Isaac shoots, firing 8 blood shots, knocking back enemies, and leaving a puddle of creep when released.
0
Lil Haunt
Lil Haunt
Fear him
  • Spawns a familiar that chases down enemies, dealing 2 damage per tick, and inflicting Fear.
1
Big Fan
Big Fan
Fat protector
  • Spawns a large orbital familiar that blocks enemy shots and deals 2 damage per tick.
2
Sissy Longlegs
Sissy Longlegs
She loves you
  • Spawns a familiar that wanders around the room and occasionally spawns Blue Spider.png blue spiders.
  • Upon contact with an enemy, it will briefly Charm them.
1
Punching Bag
Punching Bag
Scape goat
  • Spawns a familiar that walks randomly around the room and acts as a decoy, making enemies attack it instead of Isaac if it is closer than him.
1
Aries
Aries
Ramming speed
  • +0.25 speed.
  • Running into enemies while at a high speed will deal damage.
  • Prevents Isaac from taking contact damage while moving at high speed.
2
Leo
Leo
Stompy
  • Isaac can destroy obstacles by walking into them.
1
Capricorn
Capricorn
All stats up
3
Pisces
Pisces
Tears up + knock-back shot
  • +0.5 fire rate.
  • Tears have increased size and knock-back.
2
Judas' Shadow
Judas' Shadow
Sweet revenge
3
Holy Mantle
Holy Mantle
Holy shield
  • Once per room, grants a shield that negates the first instance of damage.
4
Gemini
Gemini
Conjoined friend
  • Spawns a conjoined familiar that chases enemies close to Isaac, dealing 3 damage per tick.
1
Cain's Other Eye
Cain's Other Eye
Near-sighted friend
  • Spawns a familiar that follows Isaac and fires randomly in the cardinal directions, copying all of his tear modifiers/stats, but with a 25% reduction in damage.
2
???'s Only Friend
???'s Only Friend
Controlled friend
  • Spawns a familiar that can be controlled with the shooting buttons and deals 3.5 damage per tick to enemies.
1
Samson's Chains
Samson's Chains
The ol' ball and chain
  • Attaches a ball and chain to Isaac's ankle that blocks enemy projectiles, deals damage to enemies and destroys obstacles.
1
Mongo Baby
Mongo Baby
Mongo friend
  • Spawns a familiar that follows Isaac and copies the tears of his other currently held familiars.
2
The Ludovico Technique
The Ludovico Technique
Controlled tears
  • Replaces Isaac's tears with a single controllable tear that hovers over obstacles and deals constant damage to enemies when held over them.
2
Godhead
Godhead
God tears
4
Lazarus' Rags
Lazarus' Rags
Eternal life?
1
Safety Pin
Safety Pin
Evil + range + shot speed up
1
Caffeine Pill
Caffeine Pill
Speed up + size down
  • Gives a random PillVanilla.png pill.
  • +0.3 speed.
  • -4% hitbox size.
1
Torn Photo
Torn Photo
Tears + shot speed up
3
Blue Cap
Blue Cap
HP + tears up + shot speed down
3
Latch Key
Latch Key
Luck up
1
Synthoil
Synthoil
DMG + range up
3
Mom's Pearls
Mom's Pearls
Range + luck up
2
The Wiz
The Wiz
Double wiz shot!
  • Makes Isaac's tears fire diagonally from both eyes at the same time.
  • Gives Isaac Spectral tears.
0
8 Inch Nails
8 Inch Nails
Stick it to 'em!
  • +1.5 damage.
  • Replaces Isaac's tears with nails that have increased knockback.
3
Incubus
Incubus
Dark friend
  • Spawns a familiar that follows Isaac and copies his tears and stats.
4
Fate's Reward
Fate's Reward
Your fate beside you
  • Spawns a familiar that follows Isaac and copies his damage and tear effects.
2
Lil Chest
Lil Chest
What's in the box?
  • Spawns a chest familiar that follows Isaac and has a chance to spawn a random pickup or trinket after clearing a room.
2
Sworn Protector
Sworn Protector
Protective friend
  • Spawns an orbital familiar that attracts and blocks enemy shots to itself and deals 7 damage per tick.
  • Upon blocking 10 shots in a room, it drops an Eternal Heart.png Eternal Heart.
3
Friend Zone
Friend Zone
Friendly fly
  • Spawns a fly familiar that slowly orbits Isaac and deals 3 damage per tick.
1
Lost Fly
Lost Fly
Lost protector
  • Spawns a fly familiar that moves in a straight line and circles around the first wall or obstacle it hits.
  • The fly deals 7 damage per tick.
  • Enemies that are near the fly will target the fly instead of Isaac.
2
Mr. Dolly
Mr. Dolly
Range + tears up
3
Charged Baby
Charged Baby
Bbbzzzzzt!
  • Spawns a familiar that follows Isaac. While in an uncleared room, every 30 seconds, it has a chance to spawn a random Lil Battery.png Battery pickup, add a charge to Isaac's active item or afflict Petrified to all enemies in the room for 1.3 seconds.
3
Eden's Blessing
Eden's Blessing
Tears up + your future shines brighter
  • +0.7 tears.
  • Grants a random item at the start of the next run.
3
Lil Gurdy
Lil Gurdy
A gurd of your own!
  • Spawns a GurdyJr.png Gurdy Jr. familiar that charges up while Isaac is firing, bouncing around the room when released and dealing contact damage based on its velocity.
2
Bumbo
Bumbo
Bumbo want coin!
  • Spawns a familiar that follows Isaac and picks up nearby Penny.png coins. The familiar changes level and behavior based on the number of collected coins.
1
Censer
Censer
Peace be with you
  • Spawns a familiar that follows Isaac and projects a circular aura that afflicts Slow to enemies and enemy shots within its radius.
3
Rune Bag
Rune Bag
Rune generator
  • Spawns a familiar that follows Isaac and drops a random Rune Left.png Rune or Soul Stone after clearing 7 or 8 rooms.
3
Seraphim
Seraphim
Sworn friend
  • Spawns a familiar that follows Isaac and fires Homing tears that deal 10 damage and are shot at 75% shot speed.
3
Tech X
Tech X
Laser ring tears
  • Tears are replaced with laser rings that pierce through enemies and deal damage to enemies within them.
  • Can be charged to increase the damage of the ring.
4
Tractor Beam
Tractor Beam
Controlled tears
  • +1 fire rate.
  • +2.5 range.
  • +0.16 shot speed.
  • Creates a beam directly in front of Isaac in the direction that his head is facing. Isaac's tears will always travel in the path of the beam.
3
Spider Mod
Spider Mod
Mod buddy
  • Spawns a spider familiar that wanders around the room and allows Isaac to see tear damage and health bars of enemies.
  • The familiar will inflict a random status effect to any enemy it comes in contact with.
  • Has a chance to drop a Lil Battery.png Lil' Battery or spawn a Blue Spider.png blue spider upon clearing a room.
1
Farting Baby
Farting Baby
He farts
  • Spawns a familiar that follows Isaac and blocks enemy projectiles. Has a 10% chance to fart upon blocking a projectile.
  • Farts can Charm, Poison, or knock back nearby enemies.
1
GB Bug
GB Bug
Double tap glitch
  • Spawns a familiar that follows Isaac and can be launched forward by double-tapping a fire button.
  • The familiar will reroll the first monster, trinket or pickup it hits when launched, after which it will disappear for the rest of the room.
1
Succubus
Succubus
Damage booster
  • Spawns a familiar that bounces around the room and has a dark aura around it that boosts Isaac's damage by x1.5 and deals 2.5 damage per tick to enemies within its radius.
3
Obsessed Fan
Obsessed Fan
Follows my every move...
  • Spawns a fly familiar that follows Isaac's movement with a 0.66 second delay, dealing 2 damage per tick.
0
Papa Fly
Papa Fly
Turret follower
  • Spawns a fly familiar that mimics Isaac's movement with a 0.66 second delay and fires tears at nearby enemies.
  • Tears deal Isaac's damage and are fired once per second.
1
Multidimensional Baby
Multidimensional Baby
ydduB Buddy
  • Spawns a familiar that follows Isaac's movement with a 0.66 second delay.
  • Tears that pass through the baby will be doubled and have increased shot speed.
2
Lil Loki
Lil Loki
4-way buddy!
  • Spawns a familiar that follows Isaac and shoots tears in the 4 cardinal directions.
1
Milk!
Milk!
Don't cry over it...
  • Spawns a glass familiar that spills on the floor upon taking damage.
  • After the milk spills, Isaac's fire rate is increased by 1 for the current room.
1
Binky
Binky
Tears up
3
Apple!
Apple!
Trick or treat?
  • +0.3 tears.
  • Adds a chance to fire razor blades that deal 4x Isaac's damage.
3
Dad's Lost Coin
Dad's Lost Coin
I remember this...
1
Sulfuric Acid
Sulfuric Acid
Acid tears!
  • +0.3 damage.
  • Adds a 25% chance to shoot acidic tears that destroy obstacles and open doors upon contact.
2
Glyph of Balance
Glyph of Balance
A gift from above
  • +2 Soul Heart.png Soul Hearts.
  • Modifies drops from room clears and champion enemies depending on Isaac's held amount of pickups.
2
Analog Stick
Analog Stick
360 tears!
  • +0.35 tears.
  • Allows tears to be fired diagonally by holding down 2 shooting buttons at the same time.
2
Finger!
Finger!
Watch where you point that!
  • Spawns a finger familiar that can be aimed with the shooting buttons in all directions.
  • The finger fires invisible Spectral lasers that deal 10% of Isaac's damage 10 times per second.
1
Shade
Shade
It follows
  • Spawns a familiar that mimics Isaac's movement with a 0.66 second delay and deals 5 damage per tick.
  • After dealing over 666 damage, it turns into friendly Charger.png Chargers.
0
Depression
Depression
:(
  • Spawns a cloud familiar that follows Isaac and leaves a trail of damaging blue creep on the ground that deals 2 damage per tick.
  • Has a chance to spawn damaging beams of light onto enemies that touch it.
1
Lil Monstro
Lil Monstro
Ain't he cute?
  • Spawns a miniature Monstro.png Monstro familiar that follows Isaac. It charges up and fires a cluster of tears similar to Monstro's attack.
2
Big Chubby
Big Chubby
Chub chub
  • Spawns a familiar that follows Isaac and charges across the room when Isaac fires.
  • The familiar deals 2.7 damage per tick when launched, and blocks enemy projectiles.
1
Acid Baby
Acid Baby
Pills pills pills!
  • Spawns a familiar that follows Isaac and drops a random PillVanilla.png pill after every 7 cleared rooms.
  • Upon using a pill, inflicts all enemies in the room with Poison.
2
Mom's Razor
Mom's Razor
It's sharp!
  • Spawns an orbiting razor that deals contact damage and inflicts Bleed on enemies, causing them to slowly take damage over time.
2
Bloodshot Eye
Bloodshot Eye
Bloody friend
  • Spawns an orbital familiar that shoots in the direction it's facing and deals 2 contact damage per tick.
1
Angry Fly
Angry Fly
He's violent
  • Spawns a fly familiar that orbits around a random enemy and deals 30 damage per second to enemies it comes in contact with.
1
Bozo
Bozo
Party time!
2
Buddy in a Box
Buddy in a Box
What could it be?!
  • Spawns a familiar with a random tear effect. The familiar is randomized at the start of each floor.
2
Lil Delirium
Lil Delirium
Delirious friend
  • Grants a familiar that transforms into another random familiar every 10 seconds.
2
7 Seals
7 Seals
Lil harbingers!
  • Spawns a random Harbinger familiar that changes every 10 seconds.
  • Harbingers have different behaviors and spawn themed Locusts.
2
Angelic Prism
Angelic Prism
Eclipsed by the moon
  • Spawns an orbital familiar with a large orbital radius.
  • Tears that pass through the prism split into four multi-colored tears.
3
Haemolacria
Haemolacria
I'm seeing red...
  • +1 damage.
  • ×1.5 damage multiplier.
  • x2 tear delay + 10.
  • x0.8 range multiplier.
  • Tears are now fired in an arc. Upon hitting the floor, an obstacle, or an enemy, they burst into many smaller tears in all directions.
4
Lil Spewer
Lil Spewer
Puking buddy
  • Spawns a random PillVanilla.png pill.
  • Spawns a familiar that charges up and fires creep. Using pills changes the creep type.
1
Mystery Egg
Mystery Egg
Sacrificial insemination
  • Spawns an egg familiar, which hatches a random friendly monster when Isaac is hurt once per room.
  • The power of the monster improves for each consecutive room cleared without taking damage.
1
Slipped Rib
Slipped Rib
Projectile shield
  • Spawns a bone familiar that circles around Isaac and reflects enemy shots.
2
Hallowed Ground
Hallowed Ground
Portable sanctuary
  • Spawns a white poop familiar, which turns into a White Poop.png White Poop when Isaac is hurt.
  • White poop has an aura that grants ×1.2 damage multiplier, ×2.5 fire rate multiplier, homing tears, and has a 50% chance to negate damage.
1
Pointy Rib
Pointy Rib
Stabbing time
  • Spawns a familiar that can be aimed with the firing buttons in all directions, and deals contact damage.
  • Damage dealt is equal to Isaac's tear damage and is dealt 4.29 times per second.
2
Divorce Papers
Divorce Papers
Tears up + you feel empty
3
Jaw Bone
Jaw Bone
Fetch!
  • Spawns a familiar that flies through the room while firing, dealing a flat 7 contact damage to enemies and retrieving pickups.
1
A Bar of Soap
A Bar of Soap
Tears + shot speed up
3
Orphan Socks
Orphan Socks
Speed up + your feet feel stronger
2
Eye of the Occult
Eye of the Occult
DMG up + range up + controlled tears
  • +1 damage.
  • +2 range.
  • -0.16 shot speed.
  • Isaac's tears no longer move on their own and can be controlled mid-air with the shooting buttons.
3
Immaculate Heart
Immaculate Heart
Halo of tears
  • +1 full HUD heart red full.png Red Heart container.
  • ×1.2 damage multiplier.
  • Fully heals Isaac.
  • Causes Isaac to frequently fire additional spectral tears that orbit around him until they hit the ground.
3
Psy Fly
Psy Fly
Flamboyant protector
  • Spawns an orbital fly familiar that rapidly chases and blocks enemy shots.
  • After blocking a certain amount of shots, it enters a shot cooldown period where it only orbits around Isaac, but can still block shots.
4
Mercurius
Mercurius
Speed up + you feel elusive
  • +0.4 speed.
  • Doors stay open after entering a room, even in rooms with enemies.
3
Terra
Terra
Born to rock
  • +1 damage.
  • Replaces Isaac's tears with rocks that deal extra knockback and have a chance to destroy doors and obstacles.
  • Rock tears deal varying damage between x0.5 and x2 Isaac's damage.
3
Pluto
Pluto
Size down
  • +0.7 tears.
  • -73% hitbox size.
3
Eye Drops
Eye Drops
Tears up
  • +40% fire rate to tears fired from Isaac's left eye.
3
Act of Contrition
Act of Contrition
Tears up, you feel forgiven
3
Boiled Baby
Boiled Baby
Messy friend
  • Gives Isaac a familiar that fires chaotic bursts of tears in all directions.
1
Freezer Baby
Freezer Baby
Iced iced baby
  • Spawns a familiar that follows Isaac and shoots icicles which have a chance to afflict Petrified to enemies and freeze them on kill.
2
Bird Cage
Bird Cage
Fat buddy
  • Spawns a familiar on top of Isaac's head that jumps onto the nearest enemy's head once Isaac takes damage, creating a rock wave in a random direction. After this, it will chase enemies around the room, dealing 3 damage per tick.
1
Lost Soul
Lost Soul
Protect him
  • Spawns a familiar that follows closely behind Isaac and dies in one hit, respawning at the start of the next floor.
  • Each time it survives until the next floor, it rewards Isaac with Soul Heart.png Soul Hearts, Eternal Heart.png Eternal Hearts, or an Item.
2
Lil Dumpy
Lil Dumpy
Puffy buddy
  • Spawns a Dumpy familiar that pushes away nearby enemies and projectiles just before Isaac is about to be hit, then falls asleep. He can be awoken by walking to him.
3
Lodestone
Lodestone
Magnetizing tears
  • Grants Isaac a luck-based chance to fire tears that magnetize enemies, giving them properties similar to those of Strange Attractor.png Strange Attractor.
3
Bot Fly
Bot Fly
Defense drone
  • Spawns an orbiting fly familiar that fires shielded tears at incoming enemy projectiles.
3
Evil Charm
Evil Charm
Luck up + you feel protected
2
Tinytoma
Tinytoma
Itching for revenge
  • Gives Isaac a Teratoma.png Teratoma orbital that blocks shots, deals contact damage, and splits into smaller versions of itself upon taking damage. The smaller versions break into Blue Spider.png blue spiders.
1
Fruity Plum
Fruity Plum
Bouncy friend
  • Spawns a Baby Plum.png Baby Plum familiar that propels itself diagonally around the room, firing tears behind itself as it travels.
1
False PHD
False PHD
Worse pills + evil up
  • +1 Black Heart.png Black Heart.
  • Converts all PillVanilla.png pills into their bad counterparts, but gives them positive secondary effects. Identifies all pills.
2
Sausage
Sausage
All stats up
3
Lil Abaddon
Lil Abaddon
Abyssal friend
  • Spawns a familiar that charges a miniature Maw of the Void.png Maw of the Void attack that deals 3.5 damage per tick while Isaac shoots.
2
Worm Friend
Worm Friend
Clingy buddy
  • Spawns a familiar that burrows out of the ground and grabs enemies every 5 seconds, holding them in place for 5 seconds.
  • Grabbed enemies take 4 damage per tick.
3
Inner Child
Inner Child
Let him free
  • +1 extra life.
  • On death, Isaac respawns in the current room with a Half Red Heart.png Half Red Heart, and receives +0.2 speed and -73% hitbox size.
2
Twisted Pair
Twisted Pair
Double trouble!
  • Spawns 2 familiars that float by the left and right side of Isaac, and fire tears alongside him that copy his stats and tear effects.
4
Stapler
Stapler
DMG up
  • +1 damage.
  • Prevents Isaac from firing tears from his left eye.
3

Fiend Folio Stackable Items

Name Icon Flavor Text Description Quality
>3
>3
HP up? 2 
Baby Crater
Baby Crater
Spiral shot buddy
  • Spawns a familiar that follows Isaac around the room.
  • Whilst Isaac is firing tears, Baby Crater creates a ring of tears around itself, similar to the enemy Craterface.png Craterface.
  • Tears are released outwards when Isaac stops firing.
2 
Bacon Grease
Bacon Grease
Empty calories 0 
Badump!
Badump!
10 hearts 0 
Bag of Bobbies
Bag of Bobbies
Gives bobby
  • Has a chance to spawn a Fragile Bobby familiar on room clear.
  • Fragile Bobbies act similarly to Brother Bobby.png Brother Bobby, but can die from taking enough damage from enemies.
3 
Batoomkling!
Batoomkling!
10 keys 1 
Bee Skin
Bee Skin
Buzz buzz
  • Every tear fired triggers 3 weaker tears spread around Isaac at equal angles.
  • Each time this effect triggers, the angle of all tears is incremented clockwise.
3 
Beginner's Luck
Beginner's Luck
Dwindles with time
  • +5 luck.
  • −0.5 luck per how many floors down Isaac is.
  • At minimum will grant +1 luck.
3 
Bottle of Water
Bottle of Water
Gulp it down! 1 
Box Top
Box Top
Luck up + redeemable prize 1 
Bridge Bombs
Bridge Bombs
Pit-filling blast +5 bombs
  • +5 Bomb.png Bombs.
  • Bombs fill pits when they explode.
1 
Bzzt!
Bzzt!
10 charges 0 
Cetus
Cetus
Blowhole retaliation
  • Taking damage causes Isaac to spew out a large amount of tears that leave creep.
1 
Chirumiru
Chirumiru
HP + DMG Up, Perfect Freeze 4 
Chomp Chomp!
Chomp Chomp!
10 glizzies 4 
Clutch's Curse
Clutch's Curse
What if it was purple?
  • Familiar that possesses Isaac occasionally.
  • When possessed, the next tear Isaac shoots will be a homing Ipecac.png Ipecac tear.
  • Rocks occasionally glow purple and create fire waves upon destruction.
2 
Cool Sunglasses
Cool Sunglasses
Gold rush
  • +6 coins.
  • Upon entering an uncleared room, 3 Penny.png Pennies are taken from Isaac and strewn across the room.
  • Walking near coins on the ground grants a speed up based on the distance to the coin.
  • Collecting coins damages all enemies in the room.
2 
Corn Kernel
Corn Kernel
Gotta mern 'em all!
  • Spawns a familiar that levels up when gaining multiple copies of this item:
    • Level 1: Wavy Orbital.
    • Level 2: Orbital that shoots weak explosions.
    • Level 3: Familiar that teleports and chases enemies.
    • Level 4: Familiar that teleports and lobs explosive corn.
2 
Crazy Jackpot
Crazy Jackpot
Retributive gambling
  • On taking damage, Isaac rolls for a random positive effect.
  • Effects can spawn coins or hearts, damage enemies, grant a random stat up, create a yellow creep puddle, or cause all effects at once.
1 
Crucifix
Crucifix
For your sins, they die
  • Enemies killed by tears will leave behind a short-lived ghost with an aura.
  • Standing in the aura grants a boost to tear rate and damage, and makes Isaac's tears homing.
3 
D3
D3
Reroll tears
  • Orbital dice familiar that rerolls Isaac's tears.
  • Wacky.
1 
Dad's Dip
Dad's Dip
HP up... 1 
Deimos
Deimos
Lifelong partner
  • Spawns a familiar that fires hooks that latch onto and pull enemies/pickups.
  • Remains stationary while pulling in enemies/pickups.
  • Inflicts enemies with bruising while hooked.
  • On releasing enemies, inflicts them with hemorrhaging and fires blood tears in the direction they were released.
3 
Devil's Umbrella
Devil's Umbrella
Hard to clean
  • +1 Half Soul Heart.png Half Soul Heart.
  • Shooting tears has a chance to create a flurry of weak tears that leave yellow creep.
3 
Devilled Egg
Devilled Egg
Tears up + immorality 2 
Excelsior
Excelsior
Explosive actives
  • Using active items will release fireworks, based on the item's amount of charge.
  • Fireworks will home in towards enemies and explode.
3 
Familiar Fly
Familiar Fly
Loved by many
  • Orbiting familiar that deals contact damage and blocks projectiles.
  • Swells up when close to enemies, until exploding into a ring of 10 tears that can charm enemies. Respawns some time afterwards.
  • Can charm Fly.png Fly-related enemies in close proximity.
1 
Fetal Fiend
Fetal Fiend
Bountiful 3 
Fiend's Horn
Fiend's Horn
There's a bit of him in all of us
  • Enemies have a chance to spawn a HollowFriends.png Evil Hollow Minion on death.
  • Evil Hollow Minions disappear on room clear and will not drop a Black Heart.png Black Heart.
  • Chance starts at 20% and scales to 35% at 14 luck.
  • A bonus +2.5% chance is applied for every HUD heart immoral full.png Immoral Heart Isaac has in his Health bar.
2 
Fraudulent Fungus
Fraudulent Fungus
Some stats up 2 
Glizzy
Glizzy
Hunger down 2 
GMO Corn
GMO Corn
The devil's harvest 2 
Golden Popsicle
Golden Popsicle
Luck up 2 
Golem's Orb
Golem's Orb
Lost and Found... 3 
Gorgoneion
Gorgoneion
They're shy
  • Spawns a stationary familiar that gazes at enemies in the room, petrifying them as long as they are in its sight.
3 
Grabber
Grabber
Throws Hands
  • Spawns a familiar based on Grabber from the hit video game Grabber.
  • Mirrors Isaac's movements and grabs things in front of them.
1 
Green Orange
Green Orange
May you attain enlightenment 4 
Greg The Egg
Greg The Egg
Full of surprises
  • Spawns an egg familiar that has a chance to drop a random pickup after clearing a room.
  • After being shot at by projectiles, has a chance to crack open and spawn another familiar from the Baby Shop Pool Icon.png Baby Shop Item Pool.
2 
Griddle Corns
Griddle Corns
DMG Up + it's all burnt 2 
Horncob
Horncob
Reap what you sow
  • Isaac shoots pill tears that, upon killing an enemy, has a 25% chance for Isaac to take a random pill.
1 
Host on Toast
Host on Toast
Damage + Range up 1 
Hypno Ring
Hypno Ring
Drowsing tears
  • Luck-affected chance to fire tears that makes enemies drowsy.
  • Drowsy enemies slowly fall asleep, moving and attacking increasingly slower over time.
  • Sleeping enemies remain still until they awake. They take double damage while asleep, but will instantly wake up upon taking any damage.
2 
Imp Soda
Imp Soda
Critical spit
  • Grants a chance that scales with luck to shoot critical tears that deal quintuple Isaac's damage.
3 
Isaac'D's Eulogy
Isaac'D's Eulogy
Dicing with death
  • Killing an enemy has a luck-based chance to activate a random dice effect (D6.png The D6, D20.png D20, etc.).
4 
Ka Ching!
Ka Ching!
10 coins 0 
Kinda Egg
Kinda Egg
HP up, don't swallow the prize! 1 
Lawn Darts
Lawn Darts
Hemorrhaging tears
  • Luck-affected chance to fire tears that inflict enemies with hemorrhaging.
  • Hemorrhaging enemies periodically take damage, spew blood tears randomly around themselves, and leave blood creep on the ground that damages other enemies.
2 
Leftover Takeout
Leftover Takeout
All stats up, fortune up
  • +0.3 speed.
  • 1.1× fire rate.
  • 1.5× damage.
  • +1.5 range.
  • +1 luck.
  • Luck-affected chance to fire a fortune cookie tear that deals 5% more damage and displays a fortune upon hitting an enemy.
4 
Lil Fiend
Lil Fiend
Your own little bastard
  • Spawns a familiar that flies diagonally across the room and has a chance to spawn an HollowFriends.png Evil Hollow Minion when colliding with an enemy or enemy projectile.
  • Evil Hollow Minions disappear on room clear and will not drop a Black Heart.png Black Heart.
0 
Lil Lamb
Lil Lamb
Pretends to like you
  • Spawns a familiar that charges to shoot an Ipecac.png Ipecac projectile.
  • When Isaac takes damage, has a chance to drop to the floor and target enemies automatically.
3 
Lil Minx
Lil Minx
Double-tap possesser
  • Spawns a pink Menace.png Menace familiar that charges at enemies.
  • Double-tapping the shoot button will have Lil Minx possess the nearest enemy and inflict them with berserk.
  • Double-tapping the shoot button again will have Lil Minx exit the enemy and launch a spectral tear barrage.
  • Berserked enemies periodically switch targets between Isaac and other enemies, deal and take bonus damage, move faster, and cannot die during the duration.
3 
Maria's Smash Trophy
Maria's Smash Trophy
It's the winner! 2 
Mom's Stockings
Mom's Stockings
Range up 1 
Mrs. Spooter
Mrs. Spooter
Turret pursuer
  • Spawns a blue Spooter.png Spooter familiar that pursues enemies and periodically fires tears.
1 
Nyx
Nyx
Cast
  • Grants 3 gems that can be cast while attacking, homing onto enemies to inflict damage and bruise them.
  • Bruised enemies take bonus damage from all sources based on the number of stacks applied.
3 
Ophiuchus
Ophiuchus
Serpent Bearer
  • Wiggly snake familiar that chases after enemies, poisoning them and dealing damage on contact.
  • Prioritizes chasing after enemies that are not currently afflicted with Poison.
3 
Peach Creep
Peach Creep
Creepy friend
  • Spawns a friendly Wall Creep.png Wall Creep familiar that tries to line up with enemies and shoots barrages of tears.
1 
Penny Roll
Penny Roll
Monthly allowance 2 
Pet Peeve
Pet Peeve
Double-tap antipathy
  • Grudge.png Grudge familiar that moves around randomly and deals contact damage.
  • Double-tapping a fire button will have the familiar charge in that direction.
3 
Pet Rock
Pet Rock
Movable cover
  • Spawns a pet rock familiar that can be pushed around and block shots.
  • Fills pits when pushed into them.
0 
Pinhead
Pinhead
Sewing Shot
  • Luck-based chance to shoot sewing needles that pierce and inflict enemies with sewn.
  • Sewn enemies link damage taken onto all other enemies with sewn.
3 
Pyromancy
Pyromancy
Double Tap Fireballs
  • Isaac periodically creates orbital fireballs, up to three.
  • Double-tapping the shoot button launches a fireball, leaving a trail of flames and exploding on contact.
3 
Randy The Snail
Randy The Snail
Ricochet buddy
  • Snail familiar that retracts into its shell when hit by a projectile or walked into by Isaac, and will bounce around the room.
  • Deals damage to enemies when bouncing into them.
1 
Reheated Pizza
Reheated Pizza
Daily meal 2 
Robo-Baby 3.0
Robo-Baby 3.0
It is now state-of-the-art
  • Familiar that moves diagonally towards the direction Isaac moves.
  • On contact with enemies or enemy projectiles, will fire 8 Technology.png Technology lasers around it.
0 
Rubber Bullets
Rubber Bullets
Bruising Tears
  • Luck-based chance to fire bullet tears that bruise enemies.
  • Bruised enemies take bonus damage from all sources of damage based on the number of stacks applied.
3 
Sack of Keys?
Sack of Keys?
The sack feels hot...
  • Spawns a sack familiar that follows Isaac and drops a Spicy Key.png Spicy Key after every 7 rooms cleared.
1 
Sibling Syl
Sibling Syl
Friends 'till the end
  • Familiar that follows Isaac around, shooting tears that deal 4.75 Damage.
1 
Spare Ribs
Spare Ribs
Return to sender
  • +1 Bone Heart.png Bone Heart.
  • Taking damage fires out rib projectiles that circle around Isaac.
  • Rib projectiles return to sender and are destroyed only on contact with what fired them.
  • Rib projectiles can destroy enemy projectiles.
2 
Spelling Bee
Spelling Bee
Proficiency in spelling
  • Grants buffs to all applicable stats depending on the characters of the current seed.
  • Tainted version of Community Achievement Community Achievement.
2 
Spindle
Spindle
More discs! 1 
Tea
Tea
HP up 1 
The Deluxe
The Deluxe
Every condiment 2 
The Small Pipe
The Small Pipe
Congratulations on the pipe! 2 
The Small Wood
The Small Wood
Tears up 3 
Too Many Options
Too Many Options
There's just too many!
  • Special Room doors quickly cycle between 3 random types of Special Rooms until unlocked or entered.
3 
Wimpy Bro
Wimpy Bro
Haha whee!
  • Slammer.png Slammer familiar that jumps on enemies, dealing 5 damage.
2 

Notes

  • Approximately 56.8% of all passive items (375 out of the 660 passive items, including 113 added in Fiend Folio: Reheated as of V2.8) are not considered as stackable.