The Dire Chest item pool are items and trinkets that can appear as a final payout from the 
Dire Chest. Rewards in this pool are mostly themed around 
Fiend, 
The Bastard, 
China, and the rest of the imp gang.
Active Items
| Name
|
Icon
|
Weight
|
Description
|
| Purple Putty
|
|
1
|
|
| Fiend Mix
|
|
1
|
- On use, transforms half of Isaac's health into
 Minions.
- Upon clearing a room, Minions transform back into their respective Hearts as pickups.
|
| Malice
|
|
1
|
- Upon use, turns Isaac into a black fireball which charges across the room. This gives invulnerability, deals damage to enemies hit, and leaves a trail of black creep during the charge.
|
| Risk's Reward
|
|
1
|
- Can be used to reroll an item in the
 Treasure Room to one of a higher quality.
- This is achieved by traversing a unique Psionic Cluster and fighting the
 Hermit.
|
| D2
|
|
1
|
- Can be thrown and will spin on the floor temporarily.
- Any pickups, enemies, and tears that pass through the D2 will be rerolled.
|
Passive Items
| Name
|
Icon
|
Weight
|
Description
|
| Fetal Fiend
|
|
1
|
|
| >3
|
|
1
|
|
| Devilled Egg
|
|
1
|
|
| Evil Sticker
|
|
1
|
|
| GMO Corn
|
|
1
|
|
| Lil Fiend
|
|
1
|
- Spawns a familiar that flies diagonally across the room and has a chance to spawn an
 Evil Hollow Minion when colliding with an enemy or enemy projectile.
- Evil Hollow Minions disappear on room clear and will not drop a
 Black Heart.
|
| Fiend's Horn
|
|
1
|
- Enemies have a chance to spawn a Evil Hollow Minion on death.
- Evil Hollow Minions disappear on room clear and will not drop a Black Heart.
- Chance starts at 20% and scales to 35% at 14 luck.
- A bonus +2.5% chance is applied for every
 Immoral Heart Isaac has in his Health bar.
|
| The Devil's Harvest
|
|
1
|
- Upon death, respawn as Fiend.
|
| Sack of Keys?
|
|
1
|
- Spawns a sack familiar that follows Isaac and drops a
 Spicy Key after every 7 rooms cleared.
|
| Modern Ouroboros
|
|
1
|
- Tears leave oil creep upon impact.
- Walking over oil creep will ignite it.
|
| Horncob
|
|
1
|
- Isaac shoots pill tears that, upon killing an enemy, has a 25% chance for Isaac to take a random pill.
|
| Heart of China
|
|
1
|
|
| Rubber Bullets
|
|
1
|
- Luck-based chance to fire bullet tears that bruise enemies.
- Bruised enemies take bonus damage from all sources of damage based on the number of stacks applied.
|
| Imp Soda
|
|
1
|
- Grants a chance that scales with luck to shoot critical tears that deal quintuple Isaac's damage.
|
| Prank Cookie
|
|
1
|
- Grants multi-colored tears with different status effects added in Fiend Folio.
|
| Deadly Dose
|
|
1
|
- On pickup, spawns a
 Cyanide Pill.
- Cyanide Pills provide an all stats up, but will start a death timer that will kill Isaac after 60 seconds. Taking a pill that isn't a Cyanide Pill will cure it, removing the stats and stopping the timer.
- Increases the chance for Pills to drop on room clear.
- Pills that drop while Isaac is not under the effect of a Cyanide Pill can be replaced with Cyanide Pills.
|
| Clutch's Curse
|
|
1
|
- Familiar that possesses Isaac occasionally.
- When possessed, the next tear Isaac shoots will be a homing
 Ipecac tear.
- Rocks occasionally glow purple and create fire waves upon destruction.
|
| Ball of Tar
|
|
1
|
- Adds a chance to shoot slowing tears.
- Isaac leaves a trail of slowing creep behind as he moves, impeding enemies' speed.
|
Trinkets
| Name
|
Icon
|
Weight
|
Description
|
| Fool's Gold
|
|
1
|
 Cursed Pennies have a higher chance to drop on room clear.- Cursed Pennies have a higher chance to replace
 Pennies.
|
| Chili Powder
|
|
1
|
- Transforms all
 Keys into Spicy Keys.
- Spicy Keys grant an extra key upon being picked up, but deals damage to the player.
|
| Jevilstail
|
|
1
|
- For each new room Isaac enters, grants one wacky effect in a rotating list which can be either helpful, harmful, or neither.
|
| Dealmakers
|
|
1
|
- Randomizes prices of items for sale.
- Some items for sale will have constantly shifting prices.
|
| The Middle Hand
|
|
1
|
|
| Faulty Fuse
|
|
1
|
|
| Swallowed M90
|
|
1
|
- Isaac pulls out an M90 when hurt, causing the next shot to be a fast, piercing bullet that does 3.5× Isaac's damage with self-knockback.
|
| Molten Penny
|
|
1
|
- 2% chance to activate the
 Smelter effect when picking up a Penny.
- Scales with luck.
|
| GMO Penny
|
|
1
|
- Chance to take a random pill when picking up a coin.
- Scales with luck.
|
| Fuzzy Penny
|
|
1
|
|
| Sharp Penny
|
|
1
|
|
| Chunk of Tar
|
|
1
|
|
| Hatred
|
|
1
|
- Spawns a small black clot familiar next to Isaac that moves and shoots through his same inputs.
- The clot charges forwards when a shooting key is double-tapped, leaving a trail of black creep and respawning after hitting a wall.
|
| Shard of China
|
|
1
|
- Overhealing with
 Red Hearts fills a special health bar.
- Filling this health bar accumulates a damage boost, up to +1.5 damage with 3 hearts filled.
- Smelts itself once the bar is completely filled, making the trinket's damage boost permanent.
|
| Cursed Urn
|
|
1
|
- 0.75× tear delay multiplier.
- If Isaac is about to take fatal damage, transforms them into China.
- Shatters if dropped, turning into
 Shattered Cursed Urn and losing its ability to revive.
|
| Flea of Meltdown
|
|
1
|
- Spawns an
 Orange Flea when entering a new room.
- Orange Fleas can burn enemies.
|
| Flea of Deluge
|
|
1
|
- Spawns a
 Cyan Flea when entering a new room.
- Cyan Fleas create a ring of 8 tears on hit.
|
| Flea of Pollution
|
|
1
|
|
| Flea of Propaganda
|
|
1
|
- Spawns a
 Beige Flea when entering a new room.
- Beige Fleas will charm enemies on hit.
|
| Flea Circus
|
|
1
|
- 20% chance to spawn a random Flea after killing an enemy.
|
Normal / Hard
Greed / Greedier
