Items in this pool can be found in the 
Devil Room in Greed Mode.
To see the Greed Mode Devil Room pool of items in the original game, see its page on The Binding of Isaac: Rebirth wiki.
Active Items
| Name
|
Icon
|
Weight
|
Price
|
Description
|
| Fiend Mix
|
|
1
|
|
- On use, transforms half of Isaac's health into
 Minions.
- Upon clearing a room, Minions transform back into their respective Hearts as pickups.
|
| Astropulvis
|
|
1
|
|
- On use, destroys the closest
 Rock and turns it into a large ghost.
- Using the item again will detonate all large ghosts in the room.
|
| Kalu's Severed Head
|
|
1
|
|
- Is held above Isaac's head, and controls a cone of vision.
- Enemies in the cone are petrified and take a minor amount of damage.
- Enemies killed while petrified burst into a ring of 8 tears.
|
| Malice
|
|
1
|
|
- Upon use, turns Isaac into a black fireball which charges across the room. This gives invulnerability, deals damage to enemies hit, and leaves a trail of black creep during the charge.
|
| Purple Putty
|
|
1
|
|
|
Passive Items
| Name
|
Icon
|
Weight
|
Price
|
Description
|
| Lil Fiend
|
|
1
|
|
- Spawns a familiar that flies diagonally across the room and has a chance to spawn an
 Evil Hollow Minion when colliding with an enemy or enemy projectile.
- Evil Hollow Minions disappear on room clear and will not drop a
 Black Heart.
|
| Fiend's Horn
|
|
1
|
|
- Enemies have a chance to spawn a Evil Hollow Minion on death.
- Evil Hollow Minions disappear on room clear and will not drop a Black Heart.
- Chance starts at 20% and scales to 35% at 14 luck.
- A bonus +2.5% chance is applied for every
 Immoral Heart Isaac has in his Health bar.
|
| Spare Ribs
|
|
1
|
|
- +1
 Bone Heart.
- Taking damage fires out rib projectiles that circle around Isaac.
- Rib projectiles return to sender and are destroyed only on contact with what fired them.
- Rib projectiles can destroy enemy projectiles.
|
| Imp Soda
|
|
1
|
|
- Grants a chance that scales with luck to shoot critical tears that deal quintuple Isaac's damage.
|
| Prank Cookie
|
|
1
|
|
- Grants multi-colored tears with different status effects added in Fiend Folio.
|
| Pyromancy
|
|
1
|
|
- Isaac periodically creates orbital fireballs, up to three.
- Double-tapping the shoot button launches a fireball, leaving a trail of flames and exploding on contact.
|
| The Devil's Harvest
|
|
1
|
|
- Upon death, respawn as
 Fiend.
|
| Lil Minx
|
|
1
|
|
- Spawns a pink
 Menace familiar that charges at enemies.
- Double-tapping the shoot button will have Lil Minx possess the nearest enemy and inflict them with berserk.
- Double-tapping the shoot button again will have Lil Minx exit the enemy and launch a spectral tear barrage.
- Berserked enemies periodically switch targets between Isaac and other enemies, deal and take bonus damage, move faster, and cannot die during the duration.
|
| >3
|
|
1
|
|
|
| Devilled Egg
|
|
1
|
|
|
| Toy Piano
|
|
1
|
|
- 22% chance, scaling with luck, to fire tears that doom enemies.
- Doomed enemies gain a counter that goes down every time they take damage. Upon reaching zero, the enemy takes 5× Isaac's damage and the effect is removed.
|
| Devil's Dagger
|
|
1
|
|
- Isaac throws daggers alongside his tears.
- Enemies when killed drop gems that can power up the daggers.
|
| Pet Peeve
|
|
1
|
|
 Grudge familiar that moves around randomly and deals contact damage.- Double-tapping a shoot button will have the familiar charge in that direction.
|
| Pinhead
|
|
1
|
|
- Luck-based chance to shoot sewing needles that pierce and inflict enemies with sewn.
- Sewn enemies link damage taken onto all other enemies with sewn.
|
| Lil Lamb
|
|
1
|
|
- Spawns a familiar that charges to shoot an
 Ipecac projectile.
- When Isaac takes damage, has a chance to drop to the floor and target enemies automatically.
|
| Modern Ouroboros
|
|
1
|
|
- Tears leave oil creep upon impact.
- Walking over oil creep will ignite it.
|
| Fetal Fiend
|
|
1
|
|
|
| Black Moon
|
|
0.5
|
|
- Isaac's tears gain a dark red glow. Killing an enemy with these tears creates a glowing red cross that damages enemies in an area of effect.
- Enemies killed by the cross don't spawn another cross.
|
Normal / Hard
Greed / Greedier
