Items and trinkets in this pool have a chance of appearing inside of 
Glass Chests.
Active Items
| Name
|
Icon
|
Weight
|
Description
|
| The Hourglass
|
|
1
|
- All enemies in the room are slowed for 8 seconds.
|
| The Jar
|
|
1
|
- When at full health, up to 4 extra
 Red Hearts can be stored in The Jar.
- Activating drops the stored hearts on the ground.
|
| Crystal Ball
|
|
1
|
|
| Isaac's Tears
|
|
1
|
- Each tear shot by Isaac increases item charge by one.
|
| Glass Cannon
|
|
1
|
- Fires a high-damage piercing spectral tear.
- If Isaac takes damage while holding this, he takes extra damage and it becomes
 Broken Glass Cannon.
|
| Jar of Flies
|
|
1
|
- Killing an enemy adds a fly to the jar, up to a maximum of 20.
- On use, releases
 Blue Flies equal to the number of flies in the jar.
|
| Free Lemonade
|
|
1
|
- Creates a large pool of yellow creep beneath Isaac.
|
| Jar of Wisps
|
|
1
|
- Spawns random wisps that shoot various tears, block shots, and deal contact damage.
- The number of wisps spawned increases every time the jar is used.
|
| Esau Jr.
|
|
1
|
- Swaps between the current character and Esau Jr., who has +2 flat damage and flight.
- Characters have independent items and health.
- Dying as either character ends the run.
|
| Everything Jar
|
|
1
|
- Spawns certain pickups based on how many charges it has.
- If fully charged, instead creates one of many unique effects.
|
| Shredder
|
|
1
|
- Converts all non-purchasable items in the room into an assortment of random pickups.
|
| Clear Rune
|
|
0.1
|
- Has the same effect as the rune or soul stone currently held by Isaac.
|
| Glowing Hour Glass
|
|
0.1
|
- Rewinds time, putting Isaac back in the previous room and undoing anything that happened in the current room.
- Can only be used three times per floor, after which it functions like
 The Hourglass until the next floor.
|
| Azurite Spindown
|
|
0.1
|
- On use, rerolls all trinkets in the room by subtracting their internal ID number by 1.
|
| Snow Globe
|
|
0.1
|
|
Passive Items
| Name
|
Icon
|
Weight
|
Description
|
| My Reflection
|
|
1
|
|
| Chocolate Milk
|
|
1
|
- Grants charged tears that deal greater damage when fully charged.
|
| X-Ray Vision
|
|
1
|
|
| Holy Water
|
|
1
|
- A bottle familiar that flies forward when Isaac shoots.
- It breaks upon hitting an enemy, leaving a puddle of blue creep that petrifies enemies.
|
| 20/20
|
|
1
|
- Isaac fires two tears at once, one from each eye.
- 0.8× damage multiplier.
|
| Lost Contact
|
|
1
|
- Isaac's tears can hit and destroy enemy projectiles.
- -0.15 shot speed.
|
| Cursed Eye
|
|
1
|
- Grants charged tears that can be fired in a tight burst.
- Getting hit while charging will teleport Isaac to another room.
|
| Mysterious Liquid
|
|
1
|
- Tears leave a small, short lasting pool of creep on impact or when their range is depleted.
|
| Scatter Bombs
|
|
1
|
- +5 bombs.
- Isaac's bombs explode into 2-4 tiny bombs.
|
| Night Light
|
|
1
|
- A cone of light shines in the direction Isaac is moving that slows enemies and enemy shots.
|
| Milk!
|
|
1
|
- Spawns a glass familiar that spills on the floor upon taking damage.
- After the milk spills, Isaac's fire rate is increased by 1 for the current room.
|
| Shard of Glass
|
|
1
|
- Taking damage causes Isaac to bleed, spraying a volley of blood in the direction he fires.
- Bleeding will eventually damage him, but it can be stopped by picking up a Red Heart.
|
| Angelic Prism
|
|
1
|
- Spawns an orbital familiar with a large orbital radius.
- Tears that pass through the prism split into four multi-colored tears.
|
| Rocket in a Jar
|
|
1
|
- +5 bombs.
- If Isaac is currently firing, placing a bomb will instead shoot a fast-moving, explosive rocket in the direction he's facing.
|
| Cube Baby
|
|
1
|
- Spawns an ice cube familiar that slides around when walked into.
- It slows and deals contact damage, freezing monsters it kills.
|
| Cracked Orb
|
|
1
|
- Unlocks doors and reveals a random room on the map when Isaac takes damage.
|
| Glass Eye
|
|
1
|
|
| Cool Sunglasses
|
|
1
|
- +6 coins.
- Upon entering an uncleared room, 3
 Pennies are taken from Isaac and strewn across the room.
- Walking near coins on the ground grants a speed up based on the distance to the coin.
- Collecting coins damages all enemies in the room.
|
| Golem's Orb
|
|
1
|
|
| Dr. Fetus
|
|
0.1
|
- Tears are replaced by bombs that benefit from bomb-enhancing effects and slide for a fixed time after being fired.
|
| Epic Fetus
|
|
0.1
|
- Isaac's tears are replaced with guided missiles, like those used by the
 Doctor's Remote.
|
| Soy Milk
|
|
0.1
|
- Tears are smaller and do much less damage, but fire in very rapid succession.
|
| Sacred Orb
|
|
0.1
|
- Prevents items of quality 0-1 from appearing, and items of quality 2 from appearing 33% of the time, greatly increasing the quality of items received from all item pools.
- Quest items are unaffected.
|
| Clear Case
|
|
0.1
|
- The next active item that is picked up will be assigned to the player's pocket slot.
|
| Excelsior
|
|
0.1
|
- Using active items will release fireworks, based on the item's amount of charge.
- Fireworks will home in towards enemies and explode.
|
| Heart of China
|
|
0.1
|
|
Trinkets
Normal / Hard
Greed / Greedier
