Septic Enemies
Septic Enemies are a handful of enemy variants added in the Afterbirth+ edition of Fiend Folio that would have appeared in Genesis+ Septic Shock mod's unique floor, The Septic.
Currently, the Genesis+ mod is not compatible with the Repentance DLC, and thus cannot be played alongside the Fiend Folio: Reheated update — however, the Septic enemy variants are still in the MOD's files, and can be spawned in the game through the debug console. They may also rarely appear in a few rare rooms or from waves in Greed Mode.
S'Eptic
S'Eptics are variants of 
Slammers that behave similarly to 
S'Mores, but they leave damaging green creep instead of gunpowder — as a result, they are quite a bit harder, as the creep can damage Isaac instantly if they are in the path between where S'Eptics are jumping towards.
Septic Bowler
Septic Bowlers are variants of 
Bowlers. They behave identically to their regular counterparts, however they will instead throw a Septic Bowler Ball and turn into a Septic Loafer.
Septic Loafer
Septic Loafers are variants of 
Loafers. They behave exactly the same as their regular counterparts, but will only seek Septic Bowler Balls to pick up.
Septic Bowler Ball
Septic Bowler Balls are variants of 
Bowler Ball heads thrown by Septic Bowler. They leave a trail of green damaging creep as they roll — otherwise, their behavior is the same as that of Bowler Balls.
Septic Balor
Septic Balors are variants of 
Balors that behave almost identically, except they leave green creep instead of red, and their projectiles are explosive green projectiles that explode upon landing and leave a large puddle of green damaging creep where it has landed. These projectiles do not leave creep while traveling through the air.
Limepatch
Limepatches are variants of 
Sourpatches that split into a Limepatch Head and Limepatch Body upon death — otherwise, they behave exactly the same.
Limepatch Head
Limepatch Heads act identically like their regular counterparts, but their creep is green and they explode upon death.
Limepatch Body
Limepatch Bodies behave exactly like their regular counterparts, but their projectiles leave small puddles of green damaging creep.
Septic Poly
Septic Polies are variants of 
Roly Poly that leave trail of green creep when they roll.
Septic Nimbus
Septic Nimbuses are variants of 
Nimbuses whose clouds are green, and drop down multiple explosive 
Ipecac shots instead of regular tears.
Septic Ghostse
Septic Ghostse is a variant of 
Ghostse fires volleys of explosive Ipecac shots instead of regular poop projectiles, but otherwise acts the same.
Trivia
- Some of the Septic enemies can appear in a few very rare rooms in
Chest — one room contains two Septic Loafers and a single Septic Ghostse, while a single closet room contains a Septic Bowler Ball along with some random pickups. - S'Eptics can appear as a part of the Slammer Gang effect of
The Fiend Folio. - Limepatches and their components have a chance to replace Sourpatches if the player is holding
Limestone.
