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Name Icon Flavor Text Description Quality
Risk's Reward
Risk's RewardIt's complicated
Psionic reroll. Quality up
  • Can be used to reroll an item in the Treasure Pool Icon.png Treasure Room to one of a higher quality.
  • This is achieved by traversing a unique Psionic Cluster and fighting the HermitIcon.png Hermit.
3 
The Devil's Harvest
The Devil's Harvest
Genetically modified revive
  • Upon death, respawn as FiendCoopIcon.png Fiend.
2 
The Fiend Folio
The Fiend Folio4 rooms
Summon fiendish friends
  • Summons one of Fiend Folio's bosses or enemies to assist Isaac in the room.
2