| Name
|
Icon
|
Flavor Text
|
Description
|
Quality
|
| Baby Crater
|
|
Spiral shot buddy
|
- Spawns a familiar that follows Isaac around the room.
- Whilst Isaac is firing tears, Baby Crater creates a ring of tears around itself, similar to the enemy
 Craterface.
- Tears are released outwards when Isaac stops firing.
|
2  
|
| Bag of Bobbies
|
|
Gives bobby
|
- Has a chance to spawn a Fragile Bobby familiar on room clear.
- Fragile Bobbies act similarly to
 Brother Bobby, but can die from taking enough damage from enemies.
|
3
|
| Bee Skin
|
|
Buzz buzz
|
- Every tear fired triggers 3 weaker tears spread around Isaac at equal angles.
- Each time this effect triggers, the angle of all tears is incremented clockwise.
|
3
|
| Beginner's Luck
|
|
Dwindles with time
|
- +5 luck.
- −0.5 luck per how many floors down Isaac is.
- At minimum will grant +1 luck.
|
3
|
| Birthday Gift
|
|
Careful what you wish for
|
- Replaces all newly encountered collectibles with
 Mystery Gift.
- Rerolls and special/fixed drops are not affected.
|
4
|
| Black Lantern
|
|
Silver-Lined Curses
|
- +1
 Black Heart.
- Guarantees a curse on every floor.
- Replaces curses with special new types of potentially beneficial curses.
|
2
|
| Black Moon
|
|
It all returns to nothing
|
- Isaac's tears gain a dark red glow. Killing an enemy with these tears creates a glowing red cross that damages enemies in an area of effect.
- Enemies killed by the cross don't spawn another cross.
|
2
|
| Bridge Bombs
|
|
Pit-filling blast +5 bombs
|
- +5
 Bombs.
- Bombs fill pits when they explode.
|
1
|
| Cetus
|
|
Blowhole retaliation
|
- Taking damage causes Isaac to spew out a large amount of tears that leave creep.
|
1
|
| Chaldean Axe
|
|
Cut them down!
|
- Periodically fire a piercing axe towards the closest enemy.
- The axe boomerangs back shortly after launch.
|
3
|
| Chirumiru
|
|
HP + DMG Up, Perfect Freeze
|
|
4
|
| Clutch's Curse
|
|
What if it was purple?
|
- Familiar that possesses Isaac occasionally.
- When possessed, the next tear Isaac shoots will be a homing
 Ipecac tear.
- Rocks occasionally glow purple and create fire waves upon destruction.
|
2
|
| Community Achievement
|
|
Proficiency in counting
|
- +2.71 flat damage.
- Damage boost is based on the current records in the Fiend Folio Cornmunity Discord server's counting channels.
|
3
|
| Cool Sunglasses
|
|
Gold rush
|
- +6 coins.
- Upon entering an uncleared room, 3
 Pennies are taken from Isaac and strewn across the room.
- Walking near coins on the ground grants a speed up based on the distance to the coin.
- Collecting coins damages all enemies in the room.
|
2
|
| Corn Kernel
|
|
Gotta mern 'em all!
|
- Spawns a familiar that levels up when gaining multiple copies of this item:
- Level 1: Wavy Orbital.
- Level 2: Orbital that shoots weak explosions.
- Level 3: Familiar that teleports and chases enemies.
- Level 4: Familiar that teleports and lobs explosive corn.
|
2
|
| Crazy Jackpot
|
|
Retributive gambling
|
- On taking damage, Isaac rolls for a random positive effect.
- Effects can spawn coins or hearts, damage enemies, grant a random stat up, create a yellow creep puddle, or cause all effects at once.
|
1
|
| Crucifix
|
|
For your sins, they die
|
- Enemies killed by tears will leave behind a short-lived ghost with an aura.
- Standing in the aura grants a boost to tear rate and damage, and makes Isaac's tears homing.
|
3
|
| D3
|
|
Reroll tears
|
- Orbital dice familiar that rerolls Isaac's tears.
- Wacky.
|
1
|
| Dad's Postiche
|
|
It feels yicky
|
|
3
|
| Dad's Wallet
|
|
Damage debt
|
 Shop items can be purchased when they are not affordable, with the amount owed accumulating as debt.- Debt gives a multiplicative damage down.
- Debt can be reduced by picking up coins.
- Drops a
 Credit Card upon being picked up.
|
2
|
| Deimos
|
|
Lifelong partner
|
- Spawns a familiar that fires hooks that latch onto and pull enemies/pickups.
- Remains stationary while pulling in enemies/pickups.
- Inflicts enemies with bruising while hooked.
- On releasing enemies, inflicts them with hemorrhaging and fires blood tears in the direction they were released.
|
3
|
| Devil's Abacus
|
|
Learn to count!
|
- Counting with Isaac's tears grants an increasing damage and tears up.
- To count, Isaac must fire X amount of tears and stop, with X increasing by 1 each time.
|
1
|
| Devil's Dagger
|
|
With haste comes power
|
- Isaac throws daggers alongside his tears.
- Enemies when killed drop gems that can power up the daggers.
|
3
|
| Devil's Umbrella
|
|
Hard to clean
|
- +1
 Half Soul Heart.
- Shooting tears has a chance to create a flurry of weak tears that leave yellow creep.
|
3
|
| Devilled Egg
|
|
Tears up + immorality
|
|
2
|
| Dice Bag
|
|
Gives dice
|
- Spawns a sack familiar that follows Isaac and drops a random Glass Dice after every 8 rooms cleared.
- Glass Dice mimic their respective Dice collectible and break after use.
|
3
|
| Dice Goblin
|
|
Object hoarder
|
- Spawns 3 random objects on pickup.
- Spawns 1 random object at the start of each floor.
|
1
|
| Dichromatic Butterfly
|
|
Hitbox down, Graze and Homing Amulet
|
- Isaac's hitbox size is reduced and indicated by a red marker over top of him.
- +0.2 damage for the current room when narrowly avoiding a projectile. Caps at +3 damage.
- Luck-affected chance to fire a tear with 1.25× damage and aggressive homing.
|
3
|
| Emoji Glasses
|
|
It's lit
|
- Isaac fires emoji tears that each have a unique effect.
- Cycles through 3 different emojis at a time.
|
1
|
| Excelsior
|
|
Explosive actives
|
- Using active items will release fireworks, based on the item's amount of charge.
- Fireworks will home in towards enemies and explode.
|
3
|
| Familiar Fly
|
|
Loved by many
|
- Orbiting familiar that deals contact damage and blocks projectiles.
- Swells up when close to enemies, until exploding into a ring of 10 tears that can charm enemies. Respawns some time afterwards.
- Can charm
 Fly-related enemies in close proximity.
|
1
|
| Fetal Fiend
|
|
Bountiful
|
|
3
|
| Fiend's Horn
|
|
There's a bit of him in all of us
|
- Enemies have a chance to spawn a
 Evil Hollow Minion on death.
- Evil Hollow Minions disappear on room clear and will not drop a Black Heart.
- Chance starts at 20% and scales to 35% at 14 luck.
- A bonus +2.5% chance is applied for every
 Immoral Heart Isaac has in his Health bar.
|
2
|
| Fraudulent Fungus
|
|
Some stats up
|
|
2
|
| Glizzy
|
|
Hunger down
|
|
2
|
| GMO Corn
|
|
The devil's harvest
|
|
2
|
| Golem's Orb
|
|
Lost and Found...
|
|
3
|
| Gorgoneion
|
|
They're shy
|
- Spawns a stationary familiar that gazes at enemies in the room, petrifying them as long as they are in its sight.
|
3
|
| Grabber
|
|
Throws Hands
|
- Spawns a familiar based on Grabber from the hit video game Grabber.
- Mirrors Isaac's movements and grabs things in front of them.
|
1
|
| Green Orange
|
|
May you attain enlightenment
|
|
4
|
| Griddle Corns
|
|
DMG Up + it's all burnt
|
|
2
|
| Heart of China
|
|
It's fragile
|
|
3
|
| Horncob
|
|
Reap what you sow
|
- Isaac shoots pill tears that, upon killing an enemy, has a 25% chance for Isaac to take a random pill.
|
1
|
| Host on Toast
|
|
Damage + Range up
|
|
1
|
| Hypno Ring
|
|
Drowsing tears
|
- Luck-affected chance to fire tears that makes enemies drowsy.
- Drowsy enemies slowly fall asleep, moving and attacking increasingly slower over time.
- Sleeping enemies remain still until they awake. They take double damage while asleep, but will instantly wake up upon taking any damage.
|
2
|
| Imp Soda
|
|
Critical spit
|
- Grants a chance that scales with luck to shoot critical tears that deal quintuple Isaac's damage.
|
3
|
| Infinity Volt
|
|
Double tap cord
|
- Double tap to link to an enemy with an extension cord.
- Linked enemies are charmed and continually generate arcs of electricity.
- After being linked for long enough, the enemy will explode.
|
2
|
| Lawn Darts
|
|
Hemorrhaging tears
|
- Luck-affected chance to fire tears that inflict enemies with hemorrhaging.
- Hemorrhaging enemies periodically take damage, spew blood tears randomly around themselves, and leave blood creep on the ground that damages other enemies.
|
2
|
| Leftover Takeout
|
|
All stats up, fortune up
|
- +0.3 speed.
- 1.1× fire rate.
- 1.5× damage.
- +1.5 range.
- +1 luck.
- Luck-affected chance to fire a fortune cookie tear that deals 5% more damage and displays a fortune upon hitting an enemy.
|
4
|
| Lil Fiend
|
|
Your own little bastard
|
- Spawns a familiar that flies diagonally across the room and has a chance to spawn an Evil Hollow Minion when colliding with an enemy or enemy projectile.
- Evil Hollow Minions disappear on room clear and will not drop a Black Heart.
|
0
|
| Lil Lamb
|
|
Pretends to like you
|
- Spawns a familiar that charges to shoot an Ipecac projectile.
- When Isaac takes damage, has a chance to drop to the floor and target enemies automatically.
|
3
|
| Lil Minx
|
|
Double-tap possesser
|
- Spawns a pink
 Menace familiar that charges at enemies.
- Double-tapping the shoot button will have Lil Minx possess the nearest enemy and inflict them with berserk.
- Double-tapping the shoot button again will have Lil Minx exit the enemy and launch a spectral tear barrage.
- Berserked enemies periodically switch targets between Isaac and other enemies, deal and take bonus damage, move faster, and cannot die during the duration.
|
3
|
| Mime Degree
|
|
...
|
- Summons 3-5 translucent mime blocks in the room that block enemies and their projectiles.
- When Isaac touches a mime block, it will relocate to another place in the room.
|
1
|
| Model Rocket
|
|
Accelerating tears
|
- +1.5 range.
- 2× shot speed multiplier.
- Tears accelerate from zero shot speed to normal shot speed on firing.
- Tears deal bonus damage based on their speed upon impact.
|
2
|
| Modern Ouroboros
|
|
Voice like the devil
|
- Tears leave oil creep upon impact.
- Walking over oil creep will ignite it.
|
3
|
| Mom's Stockings
|
|
Range up
|
|
1
|
| Monas Hieroglyphica
|
|
Unite the cosmos
|
|
3
|
| Mrs. Spooter
|
|
Turret pursuer
|
- Spawns a blue
 Spooter familiar that pursues enemies and periodically fires tears.
|
1
|
| Musca
|
|
Locust Bombs + Bug chaser
|
- +3 Bombs.
- Bombs spawn Locusts when they explode.
- Enemies have a luck-based chance to spawn a random Harbinger Locust on death.
|
3
|
| Nugget Bombs
|
|
Friends inside +5 bombs
|
- +5 Bombs.
- Bombs spawn a
 Brown Nugget turret fly familiar when they explode.
- Turret flies gain unique effects when combined with other bomb upgrade Items.
|
1
|
| Nyx
|
|
Cast
|
- Grants 3 gems that can be cast while attacking, homing onto enemies to inflict damage and bruise them.
- Bruised enemies take bonus damage from all sources based on the number of stacks applied.
|
3
|
| Ophiuchus
|
|
Serpent Bearer
|
- Wiggly snake familiar that chases after enemies, poisoning them and dealing damage on contact.
- Prioritizes chasing after enemies that are not currently afflicted with Poison.
|
3
|
| Page of Virtues
|
|
Your faith holds true
|
- On pickup, spawns a random wisp.
- Whenever this wisp is destroyed, spawns a new random wisp.
|
2
|
| Peach Creep
|
|
Creepy friend
|
- Spawns a friendly
 Wall Creep familiar that tries to line up with enemies and shoots barrages of tears.
|
1
|
| Peppermint
|
|
It burns! Wait, no it doesn't...
|
- Chance to fire a flame that damages and slows enemies, and freezes them into ice statues on death.
|
2
|
| Pet Peeve
|
|
Double-tap antipathy
|
 Grudge familiar that moves around randomly and deals contact damage.- Double-tapping a fire button will have the familiar charge in that direction.
|
3
|
| Pet Rock
|
|
Movable cover
|
- Spawns a pet rock familiar that can be pushed around and block shots.
- Fills pits when pushed into them.
|
0
|
| Pinhead
|
|
Sewing Shot
|
- Luck-based chance to shoot sewing needles that pierce and inflict enemies with sewn.
- Sewn enemies link damage taken onto all other enemies with sewn.
|
3
|
| Prank Cookie
|
|
Tastes like corn
|
- Grants multi-colored tears with different status effects added in Fiend Folio.
|
3
|
| Pyromancy
|
|
Double Tap Fireballs
|
- Isaac periodically creates orbital fireballs, up to three.
- Double-tapping the shoot button launches a fireball, leaving a trail of flames and exploding on contact.
|
3
|
| Randy The Snail
|
|
Ricochet buddy
|
- Snail familiar that retracts into its shell when hit by a projectile or walked into by Isaac, and will bounce around the room.
- Deals damage to enemies when bouncing into them.
|
1
|
| Robo-Baby 3.0
|
|
It is now state-of-the-art
|
- Familiar that moves diagonally towards the direction Isaac moves.
- On contact with enemies or enemy projectiles, will fire 8
 Technology lasers around it.
|
0
|
| Rubber Bullets
|
|
Bruising Tears
|
- Luck-based chance to fire bullet tears that bruise enemies.
- Bruised enemies take bonus damage from all sources of damage based on the number of stacks applied.
|
3
|
| Sack of Keys?
|
|
The sack feels hot...
|
- Spawns a sack familiar that follows Isaac and drops a
 Spicy Key after every 7 rooms cleared.
|
1
|
| Sibling Syl
|
|
Friends 'till the end
|
- Familiar that follows Isaac around, shooting tears that deal 4.75 Damage.
|
1
|
| Slippy's Guts
|
|
Distance
|
- Enemies have a chance to spawn a lingering poison fart cloud on death. The chance scales with Isaac's luck, and is proportional to the enemy's maximum health.
- Isaac's Bombs spawn a lingering poison fart cloud after exploding.
|
1
|
| Slippy's Heart
|
|
Intimacy
|
- Chance to fart while near enemies. Farts vary in type and strength.
- Fart chance scales with luck.
|
1
|
| Telebombs
|
|
Swap the bomb! +5 bombs
|
- +5 Bombs.
- A target follows behind Isaac with a delay.
- When placing a bomb, the player teleports back to the marker, and the bomb instantly explodes.
|
1
|
| The Small Wood
|
|
Tears up
|
|
3
|
| Time Itself
|
|
Multi-euclidean tears
|
- Has a chance to fire tears that cause enemies to become multi-euclidean.
- Multi-euclidean enemies can be shot through, doubling the tears.
|
3
|
| Token Bag
|
|
Gives tokens
|
- Sack Familiar that drops a
 Token every 10 rooms.
- Tokens mimic the most recent pickup Isaac has collected.
|
4
|
| Too Many Options
|
|
There's just too many!
|
- Special Room doors quickly cycle between 3 random types of Special Rooms until unlocked or entered.
|
3
|
| Toy Piano
|
|
Diabolus in musica
|
- 22% chance, scaling with luck, to fire tears that doom enemies.
- Doomed enemies gain a counter that goes down every time they take damage. Upon reaching zero, the enemy takes 5× Isaac's damage and the effect is removed.
|
3
|
| Twinkle of Contagion
|
|
Take the Shot
|
- Enemies have a chance to glow upon entering a room.
- Looking at a glowing enemy passes the effect onto Isaac, giving him a stat boost while under the effect.
- After a period of time, the glowing effect will jump from Isaac to a random enemy.
|
2
|
| Wimpy Bro
|
|
Haha whee!
|
 Slammer familiar that jumps on enemies, dealing 5 damage.
|
2
|
Lemegeton and copied by 
Modeling Clay.
